Pseudobulbar affect is the latest name for a neurological condition previously referred to as emotional lability, reflex crying and involuntary. PBA is a condition that causes uncontrollable crying and/or laughing that happens suddenly and frequently. A person having a PBA crying spell may cry when they don’t feel sad or when they only feel a little bit sad. Someone having a PBA laughing spell may laugh when they don’t. The most common symptom of pseudobulbar affect is mood-incongruent behavior. Laughing hysterically at a funeral. Uncontrollable crying when someone tells.


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See Table 2 for more details. Guidelines In a review of the available evidence-based guidelines, two treatment guidelines are available on the management of PBA: Role of the Pharmacist Neurologic conditions compounded with PBA are complex to manage due to multiple factors, including the heterogeneity pseudobulbar syndrome neurologic pseudobulbar syndrome, comorbidities, care management by multiple prescribers, and consequential polypharmacy issues.

Additionally, the pharmacist has access to the multiple medications being prescribed and can provide support for pharmacotherapy management of the neurological conditions and existing comorbidities.

Review of the Diagnosis and Management of Pseudobulbar Affect

A key consideration for pharmacists in pseudobulbar syndrome patients prescribed Neudexta is being able to understand the therapeutic moiety, dextromethorphan, and the requirement of CYP2D6 inhibition from quinidine sulfate in order to maintain therapeutic levels.

Pharmacogenomic research pseudobulbar syndrome shown a large variation in the enzyme activity of CYP2D6. This variation ranges from poor metabolizer to ultra-rapid metabolizer, making pharmacokinetic and pharmacogenomic considerations an important factor when selecting treatment.

The quinidine component of Nuedexta is not expected to contribute to pseudobulbar syndrome effectiveness of Nuedexta in PMs, but adverse events with the quinidine are still possible. In those patients who may be at risk of significant toxicity due pseudobulbar syndrome quinidine, genotyping to determine if they are PMs should be considered prior to making the decision to treat with Nuedexta.

Depending on the selected PBA treatment agent, there may be a need for additional vigilance on potential pharmacodynamic issues such as risks for cardiotoxicity, serotonin syndrome, and potential negative effects on the neurological condition or comorbidities, especially when treating with certain antidepressants.

Pseudobulbar affect: prevalence and management

Pharmacists are able to address the gaps in care that may contribute to patient-safety risks in a treatment plan when multiple prescribers are involved in pseudobulbar syndrome care pseudobulbar syndrome a single patient.

Treatments for PBA target serotonin, norepinephrine, and glutamate to reduce severity and episode frequency.

Neurologic conditions compounded with PBA are complex pseudobulbar syndrome manage. Schiffer Pseudobulbar syndrome, Pope LE. Such sudden, frequent, extreme, uncontrollable emotional outbursts may lead to social withdrawal and interfere with activities of daily living, social and professional pursuits, and reduce overall healthcare.

Pseudobulbar affect - Symptoms and causes - Mayo Clinic

In depression and grief syndromes, crying is typically a sign of sadness, whereas pseudobulbar syndrome pathological displays of crying which occur in PBA are often in contrast to the underlying mood, or greatly in excess of the mood or eliciting stimulus.

In addition, a key to differentiating depression from PBA is duration: PBA episodes are sudden, occurring in a pseudobulbar syndrome episodic manner, while crying in depression is a more sustained presentation and closely relates to the underlying mood state.

This knowledge has permitted effective treatment for many years with antidepressants, particularly tricyclic antidepressants and selective serotonin reuptake inhibitors.

  • Review of the Diagnosis and Management of Pseudobulbar Affect
  • Pseudobulbar Affect Uncontrollable Crying & Laughing is Fully Treatable
  • Pseudobulbar affect

The upside is that after 17 pseudobulbar syndrome of dealing with PBA, this assessment takes roughly 1. Pseudobulbar affect is the latest name for a neurological condition previously referred to as pseudobulbar syndrome lability, reflex crying and involuntary emotional expression disorder, among other names.

Someone with PBA has involuntary bouts of crying, laughter or episodic anger. The outburst may be out of proportion, e.

Pseudobulbar Affect (PBA)

It can appear as mood incongruent, so the person may laugh when they hear sad news. Or there may be rapid switching pseudobulbar syndrome laughing and crying.

Pseudobulbar affect typically occurs pseudobulbar syndrome people with certain neurological conditions or injuries, which might affect the way the brain controls emotion.

If you have pseudobulbar affect you'll experience emotions normally, but you'll sometimes express them in an exaggerated or inappropriate way. pseudobulbar syndrome


As a result, the condition pseudobulbar syndrome be embarrassing and disruptive to your daily pseudobulbar syndrome. Depression symptoms are longer in duration and are congruent to the mood. The causes of pseudobulbar affect are secondary in nature. If you are experiencing symptoms of this disorder, there is a biological cause of the condition—either a brain injury or some type of neurological condition.

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