Liposomes are the most common and well-investigated nanocarriers for targeted drug delivery. They have improved therapies for a range of. In book: Advanced Biomaterials and Biodevices, Chapter: Recent Advances with Liposomes as Drug Carriers, Publisher: John Wiley & Sons. Liposomes are used as carriers for controlled drug delivery, which decreases toxic effects of drugs in the body; the drug will be protected from the external environment, and hence won't target unintended tissues. Also, it is hard to sterilize liposomes since phospholipids' bilayer is sensitive to heat.Liposomes as a Drug · Basic structure · Different Types of · Liposome usage.
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liposomes as drug carriers Advantages of liposomes as a drug delivery system for antimicrobials are: While liposomes can be formulated to have a long circulating time in the body, keeping the constant level of the drug for a longer time. Factors that influence the circulation time are: Liposomes protect some drugs against chemical and immunological breakdown, as well as protecting them against the effect of enzymes.
Liposomes as drug carriers - WikiLectures
Liposomes used as target selective Structure and make-up of the cell membranes is an important factor in reaction of cells. This can be exploited for drug targeting by inducing specific cells to react to and absorb the liposomes.
liposomes as drug carriers
The membrane surface structure can be modified liposomes as drug carriers specific drug targeting; either by changing the charge on the membrane, or adding specific proteins, antibodies or immunoglobulins.
It increases the affinity of liposomes to specific cells.
Experimenting with liposomes include: Liposomes can be made to just interact with specific organisms [ 5 ]. In order to lower toxicity, liposomes are made to avoid certain areas, also known as siteavoidance- therapy.
Liposomes as drug carriers: a technological approach.
Enhanced drug activity against intracellular pathogens Various formulations of liposomes have been tested for many years against the entire host of intracellular parasites and other pathogens. Liposomes as drug carriers has been used to great success in the treatment of leishmaniasis as they are actively removed in vivo by the macrophages which are infected with Leishmania.
The modified encapsulated drug is times more effective than the free drug in the treatment of Leishmania in hamsters [ 39 ].
These findings were followed by other studies confirmed these types of successes with leishmaniasis. In studies of anti-tuberculosis drugs like clarithromycin, isoniazid and rifampicin, the efficacy of each drug was significantly higher when compared to the free form of the drug [ 40 ].
Other studies showed lowered liposomes as drug carriers to surrounding tissues.
Liposomes for Drug Delivery
This lowered toxicity is especially important with drugs liposomes as drug carriers are in themselves very toxic, like the drugs that are currently available to treat Trypanosoma brucei and Trypanosoma cruzi. Even though the in vivo effect against the parasite is not significantly better than the free drug, the liposomes did have a protective effect against the toxicity of the drugs used in certain instances.
The main objective of encapsulating anti-malarial drugs in liposomes is to lower the adverse effects, providing sustained release and protecting the drug from being broken down. In a study, the maximum plasma concentration was increased in a shorter time for encapsulated liposomes.
Advances and Challenges of Liposome Assisted Drug Delivery
The time taken for the drug concentration to reach its maximum level get shortened. Antimalarials used earlier that have been used for entrapment in liposomes include chloroquine and primaquine. It becomes quite clear that liposomes can become a great asset in the battle against malaria.
It has been proved that liposomes are able to overcome bacterial resistance in some cases.
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